Background: Aluminum phosphide(ALP) is a fumigant used recently for suicide, Liver failure is the common reason for death. Aim of the work: The current work was done to assess the effects of erdosteine and exogenous (NADPH) against (ALP) acute hepatotoxicity. Serum levels of hepatic enzymes (ALT, AST) and oxidative stress parameters (MDA, CAT, and GSH) in liver tissue were measured. Materials and Methods: 54 male adult albino rats were divided into 7 groups(each 6 rats); 4 control groups (negative, solvent, erdosteine, NADPH ), then 3 test groups; AlP group (12 mg/kg orally), AlP (12 mg/kg orally) + erdosteine (150 mg/kg orally) group, AlP (12 mg/kg orally) + NADPH (16 mg/kg intravenously) group. Blood samples were collected after 8 hours, the abdominal cavity was incised to remove the liver for histopathological examination and to measure the oxidative stress parameters in liver tissue. Results: Poisoning with AlP can cause elevation of serum (ALT, AST) with a marked increase in (MDA) and a decrease in catalase enzyme level and GSH. Combined administration of erdosteine with AlP improved serum levels of ALT and AST and improved the levels of CAT and GSH, besides decreasing the MDA level. Combined administration of NADPH with AlP markedly decreased the serum levels of ALT and AST, a marked decrease in MDA level, and a marked increase in the CAT and GSH levels. Histopathological examination of liver tissues confirmed the results. Conclusion: The administration of erdosteine and exogenous NADPH may be helpful in improving ALP hepatotoxicity