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Strelitzia reginae Leaves: Phytochemical Elucidation and Antimicrobial Assessment on Clinical Isolates and Standard Strains

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Last updated: 27 Dec 2024

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Abstract

Strelitzia reginae is used in some African countries as a traditional medicine with very few
phytochemical and biological assessments. The study aims to isolate and structure elucidate of S. reginae
phytoconstituents using different chromatographic and spectral techniques. In addition to, antimicrobial
assessment of ethyl acetate and n-butanol fractions on both clinical isolates and standard strains. Strelitzia
reginae belongs to the family Strelitziaceae which is a rich source of biologically active phytoconstituents and
has diverse therapeutic values. Strelitzia reginae leaves were fractionated into ethyl acetate and n-butanol, and
five compounds were detected. Compounds were identified as kaempferol (1), quercetin (2), daucosterol (3),
vitexin (4), and rutin (5). The isolated compounds were elucidated by their NMR and ESI-MS spectral data.
Antimicrobial activity of Strelitzia reginae ethyl acetate and n-butanol fractions screened against six different
bacterial strains (three Gram-positive, three Gram-negative, and one fungus isolate). Both fractions showed
antimicrobial activities against Klebsiella pneumonia and Staphylococcus aureus which is methicillinresistant (MRSA) strains. As well, the activity of antimicrobial was detected against Proteus mirabilis clinical
isolate from urine and MRSA. On the other hand, both fractions showed inadequate antimicrobial activities
against the Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans clinical isolates compared
to reference drugs. The antimicrobial results were in accordance with previously reported folk uses and
attributed to the isolated phytoconstituents.

DOI

10.21608/aijpms.2023.178758.1181

Keywords

Antimicrobial, clinical isolates, Flavonoids, MRSA, sterols, Strelitzia reginae

Authors

First Name

Asmaa

Last Name

Mahmoud

MiddleName

A.

Affiliation

Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University (Girls), Cairo , Egypt

Email

asmaaabdallah012@gmail.com

City

-

Orcid

https://orcid.org/00

First Name

Marwa

Last Name

Abu Bakr

MiddleName

S.

Affiliation

Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University (Girls), Cairo , Egypt

Email

marwa.elaraby@gmail.com

City

-

Orcid

0000-0003-0798-5394

First Name

Hatem

Last Name

Abbass

MiddleName

S.

Affiliation

Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University (Boys), Cairo11884 , Egypt., Department of Pharmacognosy, Faculty of Pharmacy, Sinai University - Kantara Branch, Ismailia 41636, Egypt.

Email

hsam8406@azhar.edu.eg

City

cairo

Orcid

0000-0002-8518-9724

First Name

Shaimaa

Last Name

Azzam

MiddleName

M.

Affiliation

Department of Biochemistry, Egyptian Drug Authority (EDA), Formerly National Organization for Drug Control and Research (NODCAR), Giza, Egypt.

Email

dr.shaimaaazzam5@gmail.com

City

-

Orcid

0000-0003-2658-5783

First Name

Nagwan

Last Name

El Menofy

MiddleName

Galal

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University (Girls), Cairo, Egypt.

Email

nagwan.elmenofy@azhar.edu.eg

City

-

Orcid

0000-0001-6928-9170

First Name

Abd El‑Salam

Last Name

Mohammed

MiddleName

I.

Affiliation

Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University (Boys), Cairo11884 , Egypt.

Email

abdelsalamibrahim@azhar.edu.eg

City

cairo

Orcid

0000-0002-5554-9602

Volume

4

Article Issue

1

Related Issue

44808

Issue Date

2024-01-01

Receive Date

2022-12-06

Publish Date

2024-01-01

Page Start

52

Page End

61

Print ISSN

2735-4598

Online ISSN

2735-4601

Article File

AIJPMS_Volume 4_Issue 1_Pages 52-61.pdf

PDF . 778.2kB

Link

https://aijpms.journals.ekb.eg/article_330537.html

Detail API

https://aijpms.journals.ekb.eg/service?article_code=330537

Order

5

Type

Original research articles

Type Code

1,562

Publication Type

Journal

Publication Title

Azhar International Journal of Pharmaceutical and Medical Sciences

Publication Link

https://aijpms.journals.ekb.eg/

MainTitle

Strelitzia reginae Leaves: Phytochemical Elucidation and Antimicrobial Assessment on Clinical Isolates and Standard Strains

Details

Type

Article

Created At

27 Dec 2024