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306653

HPLC Quantitative Analysis of Two Major Flavonoids and Antimicrobial Effectiveness Against Multi-Drug Resistant Bacteria of Different Parts of Khaya senegalensis

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Last updated: 04 Jan 2025

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Abstract

Flavonoids are an important group of plant secondary metabolites that are widely used as powerful antioxidants in the management of a variety of illnesses, including inflammatory joint diseases, atherosclerosis, diabetes, in addition to free radical-induced degenerative eye disorders, cancer, dementia, and stroke. The main flavonoids of K. senegalensis plant are quercitrin and rutin. This work aims to determine the quercitrin and rutin content in methanolic extracts of K. senegalensis leaves, stems and fruits in order to determine the most productive part of these bioflavonoids by utilizing a precise HPLC quantitative method. HPLC analysis showed that leaf had the highest yield of quercitrin and rutin among the three parts (2.454 and 0.776 g/kg respectively), the stem had 1.812 and 0.286 g/kg, while fruit had a small amount of quercitrin and had no rutin. Examining certain antibiotic-resistant microorganisms' susceptibility to the antibacterial effects of methanolic extracts of leaves, fruits, and stems concerning the MIC values revealed that the mixture of quercitrin and rutin as the major flavonoids of K. senegalensis in the three different parts the highest degree, Following that are the leaf and stem extracts, however the fruit extract shows no antibacterial action.

DOI

10.21608/aijpms.2023.196073.1196

Keywords

Khaya senegalensis, meliaceae, quercitrin, Rutin, HPLC, Antibiotic-resistant bacteria

Authors

First Name

Amal

Last Name

Yassin

MiddleName

S

Affiliation

Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, P.O. Box 11884, Nasr City, Cairo, Egypt

Email

amallbrahem.52@azhar.edu.eg

City

-

Orcid

-

First Name

Salwa

Last Name

Abu El Wafa

MiddleName

A

Affiliation

Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, P.O. Box 11884, Nasr City, Cairo, Egypt

Email

salwaabuel-wafa.pharmg@azhar.edu.eg

City

Cairo

Orcid

0000-0001-7165-4077

First Name

Nagwan

Last Name

El Menofy

MiddleName

G

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11884, Egypt

Email

nagwan.elmenofy@azhar.edu.eg

City

cairo

Orcid

0000-0001-6928-9170

First Name

Amal

Last Name

Elmerigy

MiddleName

H

Affiliation

Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University, P.O. Box 11884, Nasr City, Cairo, Egypt

Email

a-elmerigy@hotmail.com

City

Cairo

Orcid

0000-0003-2212-6686

First Name

Mohamed

Last Name

Marzouk

MiddleName

-

Affiliation

Department of Tanning Materials and Leather Technology, Chemical Industries Research Institute, National Research Center National Research Centre, 33 El‑Bohouth St. (Former El‑Tahrir St.), Dokki, Cairo 12622, Egypt.

Email

msmarzouk@yahoo.co.uk

City

Cairo

Orcid

0000-0002-1344-0617

Volume

4

Article Issue

1

Related Issue

44808

Issue Date

2024-01-01

Receive Date

2023-02-25

Publish Date

2024-01-01

Page Start

32

Page End

39

Print ISSN

2735-4598

Online ISSN

2735-4601

Article File

AIJPMS_Volume 4_Issue 1_Pages 32-39.pdf

PDF . 540.5kB

Link

https://aijpms.journals.ekb.eg/article_306653.html

Detail API

https://aijpms.journals.ekb.eg/service?article_code=306653

Order

3

Type

Original research articles

Type Code

1,562

Publication Type

Journal

Publication Title

Azhar International Journal of Pharmaceutical and Medical Sciences

Publication Link

https://aijpms.journals.ekb.eg/

MainTitle

HPLC Quantitative Analysis of Two Major Flavonoids and Antimicrobial Effectiveness Against Multi-Drug Resistant Bacteria of Different Parts of Khaya senegalensis

Details

Type

Article

Created At

27 Dec 2024