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Pregabalin and mecobalamin combination in the management of refractory neuropathic pain: a potential alternative to early surgery in disco-radicular conflicts.

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Last updated: 04 Jan 2025

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Abstract

Context and Objective: Neuropathic pain is pain resulting from injury to the nervous system. They are said to be peripheral when they are consecutive to a lesion of the peripheral nervous system and can concern a plexus, a root or a truncular attack. The aim of this study is to establish the interest of a combination of Pregabalin and Mechobalamin in the medical management of refractory neuropathic pain in the pre-operative period, and to highlight its advantages.
Patients and methods: This is a cross-sectional analytical study with a duration of 12 months from 30 September 2021 to 30 September 2022. Patients were divided into 2 groups: Pregabalin for group A and Pregabalin + Mecobalamin for group B. Patients who did not receive Pregabalin or Pregabalin + Mecobalamin were not included. Anonymity and confidentiality were preserved. Data were entered into Epi-Info 7.1.4.0 and analysed in STATA/SE 11.2.
Results: In 81.82% of the patients in group A, an indication for surgery was given after three (3) months of evolution against 18.18% of group B in whom surgery was performed after three (3) months of evolution.
Conclusion: This study shows that the fixed combination of pregabalin and mecobalamin gives the neurosurgeon time to prepare the operation. Its "minimal effective dose" power preserves the patient from intoxication and dependence.

DOI

10.21608/pajn.2023.190195.1087

Keywords

Neuropathic pain, Pregabalin, Mecobalamin, alternative, Surgery

Authors

First Name

Elhadji Cheikh Ndiaye

Last Name

SY

MiddleName

-

Affiliation

Neurosurgery Department, Fann’s national teaching hospital, Dakar, Senegal, BP: 5035.

Email

cheikh-sy@live.fr

City

senegal

Orcid

-

First Name

Hugues Ghislain

Last Name

Atakla

MiddleName

-

Affiliation

Neurosurgery Department, Fann’s national teaching hospital, Dakar, Senegal, BP: 5035.

Email

neuroscience.ghislain@gmail.com

City

Dakar

Orcid

https://orcid.org/00

First Name

Maguette

Last Name

MBAYE

MiddleName

-

Affiliation

Neurosurgery Department, Fann’s national teaching hospital, Dakar, Senegal, BP: 5035.

Email

maguette.mbaye8@gmail.com

City

Senegal

Orcid

-

First Name

Mbaye

Last Name

THIOUB

MiddleName

-

Affiliation

Neurosurgery Department, Fann’s national teaching hospital, Dakar, Senegal, BP: 5035.

Email

thioubmbaye@gmail.com

City

Senegal

Orcid

-

First Name

Nantenin

Last Name

DOUMBIA

MiddleName

-

Affiliation

Neurosurgery Department, Fann’s national teaching hospital, Dakar, Senegal, BP: 5035.

Email

nandoumbia@gmail.com

City

Senegal

Orcid

-

First Name

Pape Sandène

Last Name

NDIAYE

MiddleName

-

Affiliation

Neurosurgery Department, Fann’s national teaching hospital, Dakar, Senegal, BP: 5035.

Email

papesandene105@gmail.com

City

Senegal

Orcid

-

First Name

Adja Aissatou

Last Name

KEBE

MiddleName

-

Affiliation

Neurosurgery Department, Fann’s national teaching hospital, Dakar, Senegal, BP: 5035.

Email

adjakebe94@gmail.com

City

Senegal

Orcid

-

First Name

Alioune Badara

Last Name

THIAM

MiddleName

-

Affiliation

Neurosurgery Department, Fann’s national teaching hospital, Dakar, Senegal, BP: 5035.

Email

diof76@yahoo.fr

City

Senegal

Orcid

-

First Name

Momar Code

Last Name

BA

MiddleName

-

Affiliation

Neurosurgery Department, Fann’s national teaching hospital, Dakar, Senegal, BP: 5035.

Email

bamcode@hotmail.com

City

Senegal

Orcid

-

Volume

18

Article Issue

1

Related Issue

42028

Issue Date

2023-06-01

Receive Date

2023-01-28

Publish Date

2023-06-01

Page Start

69

Page End

71

Print ISSN

1319-6995

Online ISSN

2735-4482

Article File

PAJN_Volume 18_Issue 1_Pages 69-71.pdf

PDF . 797.5kB

Link

https://pajn.journals.ekb.eg/article_304611.html

Detail API

https://pajn.journals.ekb.eg/service?article_code=304611

Order

11

Type

Original Articles

Type Code

1,544

Publication Type

Journal

Publication Title

Pan Arab Journal of Neurosurgery

Publication Link

https://pajn.journals.ekb.eg/

MainTitle

Pregabalin and mecobalamin combination in the management of refractory neuropathic pain: a potential alternative to early surgery in disco-radicular conflicts.

Details

Type

Article

Created At

27 Dec 2024