Human resources are the most critical resource for travel agencies in today's extremely competitive business environment. Although employees of travel agencies should possess intelligence, job knowledge, advanced skills, and time management ability, they will not advance in their careers or exert the ideal efforts unless they are well motivated. The research aims to analyze the effect of motivation on job satisfaction at travel agencies in Egypt. To achieve that, this research used the descriptive analytical approach, where a questionnaire was prepared and distributed to a random sample of four hundred and twenty (420) employees of travel agencies in Egypt. The questionnaires were analyzed using descriptive statistics, reliability analysis, Pearson correlation, and regression analysis with the support of SPSS 25.0. The research reached several results, including that there is a positive and significant relationship between the reasons employees choose to work in travel agencies and the factors that motivate them to perform their jobs well. The research thus recommended that the travel agency managers prioritize employee morale since an employee with high morale will be more committed to the job.