Background: The etiology of acute coronary syndrome (ACS), has been linked to lifestyle risk factors and chronic infections like those caused by Helicobacter pylori. The role of H. pylori, has been investigated in the context of cardiovascular diseases due to its potential involvement in atherosclerotic plaque destabilization.
Objectives: To evaluate the association between H. pylori infection and clinical outcomes in patients presenting with ACS.
Patients and methods: The cohort study involved 100 ACS patients and 50 age-matched healthy controls from Sohag University Hospital. Clinical evaluations, laboratory blood tests, H. pylori antigen testing in stool samples, electrocardiograms, and echocardiography were performed.
Results: The ACS patients had a significantly higher mean age and BMI compared to the control group. H. pylori - infection was detected in 48% of ACS patients compared to 60% in the control group; this difference was not statistically significant (p>0.05). The relationship between H. pylori - infection and ACS clinical parameters was not statistically significant (p>0.05). Additionally, there were no significant differences between ACS patients with and without H. Pylori regarding cardiac arrest, cardiogenic shock, reinfarction or cerebrovascular stroke (CVS)  (p>0.05).
Conclusion: The study found no significant differences in the presence of H. pylori infection between ACS patients and healthy controls. Additionally, H. pylori infection did not influence the clinical parameters or outcomes in patients with ACS.