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Hormonal changes aggravate premenstrual tension syndrome in obese women and beneficial roles of combined pharmacological therapies: A randomized controlled trial

Article

Last updated: 27 Dec 2024

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Subjects

-

Tags

Biochemistry and Molecular Biology
Laboratory medicine.
Obstetrics and Gynecology.
Pharmacology and therapeutics

Abstract

Background: The recurring psychological, behavioural, and physical symptoms of premenstrual tension syndrome (PTS) are related to the luteal phase of the menstrual cycle. Its development may be influenced by hormonal influences.
Objectives: To investigate the effects of catecholamines on PTS and possible improvements upon using pharmacological treatments.
Patients and methods: After agreement of participants and ethical committee approval, this randomized controlled trial enrolled 60 obese women with PTS who were split into younger (18-39 years) and older (40-48 years) age groups in comparison to an age-matched healthy control group. All of the study participants' serum levels of adrenaline (epinephrine), and norepinephrine were measured. Utilizing pertinent rating scales, a few psychosomatic PTS symptoms (headache, backache, and stomach bloating) were also assessed.
Results: Compared to the control group, obese women with PTS had significantly higher serum levels of adrenaline, and noradrenaline (p<0.05). Utilizing a combination of therapies, including Metformin, Amiloride/ Hydrochlorthiazide, a calorie-restricted diet, walking exercises, and either Vitazinc®, or Royal vitamin G, significantly (p< 0.01) reduced the hormonal abnormalities. In women with PTS, symptoms of headache, backache, and stomach bloating significantly increased (p< 0.001). Utilizing the combined treatments dramatically improved all of that. In conjunction with the normalization of serum hormone levels, such combined therapies considerably reduced the levels of the aforementioned hormones in the blood and the intensity of all the analysed psychosomatic symptoms (p<0.001).
Conclusion: PTS is related to obesity and is linked to higher serum catecholamines. There were improvements in hormonal abnormalities and psychosomatic symptoms with the given pharmacological treatments.

DOI

10.21608/svuijm.2024.304506.1933

Keywords

Premenstrual tension syndrome, Backache, Abdominal bloating, headache, Serum adrenaline, Noradrenaline, Royal vitamin G, Vitazinc

Authors

First Name

Hytham Mahmoud

Last Name

Abdel-Latif

MiddleName

-

Affiliation

Department of Medical Pharmacology, Faculty of Medicine, Sohag University, Sohag , Egypt

Email

hytham20042004@yahoo.com

City

-

Orcid

0009-0007-8319-171X

First Name

Amal Yaseen

Last Name

Zaman

MiddleName

-

Affiliation

Department of Gynecology & Obstetrics, Taibah Faculty of Medicine, Taibah University, Al-Madinah, Saudi Arabia.

Email

-

City

-

Orcid

-

First Name

Rawan

Last Name

Bafail

MiddleName

-

Affiliation

Department of Pharmaceutics and Pharmaceutical Industries, College of Pharmacy, Taibah University, Medina, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Raghad A.

Last Name

Mostafa

MiddleName

-

Affiliation

Department of Clinical and Chemical Pathology, Tanta Faculty of Medicine, Tanta University, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed M.

Last Name

Mabrouk

MiddleName

-

Affiliation

Department of Internal Medicine, Tanta Faculty of Medicine, Tanta University, Tanta, Egypt

Email

-

City

-

Orcid

-

First Name

Hanan Yousef

Last Name

Aly

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Sohag University, Sohag , Egypt.

Email

-

City

-

Orcid

-

First Name

Nivin

Last Name

Baiomy

MiddleName

-

Affiliation

Department of Clinical and Chemical Pathology, Tanta Faculty of Medicine, Tanta University, Egypt.

Email

-

City

-

Orcid

-

First Name

Amira A.

Last Name

Abdelnaby

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt. & Department of Restorative Dentistry and Basic Medical Sciences, Faculty of Dentistry, University of Petra, Amman 11196, Jordan.

Email

-

City

-

Orcid

-

First Name

Hend Mohamed

Last Name

Hussein

MiddleName

-

Affiliation

Al-Rayyan National College of Medicine, Al-Madinah, Saudi Arabia. & Department of Medical Parasitology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Samer A.

Last Name

El-Sawy

MiddleName

-

Affiliation

Department of Restorative Dentistry and Basic Medical Sciences, Faculty of Dentistry, University of Petra, Amman 11196, Jordan. & Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag , Egypt.

Email

-

City

-

Orcid

-

First Name

Salah Mohamed

Last Name

El Sayed

MiddleName

-

Affiliation

Department of Basic Medical Sciences, Faculty of Medicine, Sohag University, Sohag, Egypt. & Department of Basic Medical Sciences, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Hussam

Last Name

Baghdadi

MiddleName

-

Affiliation

Department of Basic Medical Sciences, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

Email

hussam.baghdadi@gmail.com

City

-

Orcid

-

First Name

Alfarazdeg Ageed

Last Name

Saad

MiddleName

-

Affiliation

Department of Basic Medical Sciences, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Abdelfattah

Last Name

Alayoubi

MiddleName

-

Affiliation

Department of Basic Medical Sciences, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Reda S.

Last Name

Yousef

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag , Egypt.

Email

-

City

-

Orcid

-

Volume

7

Article Issue

2

Related Issue

47977

Issue Date

2024-07-01

Receive Date

2024-07-16

Publish Date

2024-07-01

Page Start

313

Page End

324

Print ISSN

2735-427X

Online ISSN

2636-3402

Article File

SVUIJM_Volume 7_Issue 2_Pages 313-324.pdf

PDF . 352.7kB

Link

https://svuijm.journals.ekb.eg/article_369276.html

Detail API

https://svuijm.journals.ekb.eg/service?article_code=369276

Order

369,276

Type

Original research articles

Type Code

1,520

Publication Type

Journal

Publication Title

SVU-International Journal of Medical Sciences

Publication Link

https://svuijm.journals.ekb.eg/

MainTitle

Hormonal changes aggravate premenstrual tension syndrome in obese women and beneficial roles of combined pharmacological therapies: A randomized controlled trial

Details

Type

Article

Created At

27 Dec 2024