Background: The most common kind of birth abnormality is a heart problem. When the heart doesn't form properly during pregnancy or birth, it's called a congenital heart defect. CHDs are associated with high rates of mortality and disability. Multiple processes are controlled by the cytokine growth differentiation factor-15 (GDF-15). Because of its continuous overexpression in both CVD and diabetes, GDF-15 is recommended as a biomarker for the existence and severity of both illnesses. In contrast, a large body of research indicates that GDF-15 has a protective role in the regulation of inflammation, endothelial cell function, insulin sensitivity, and weight gain, and is cardioprotective in myocardial infarction (MI). Objectives: Aim of the work is to give highlight on (GDF15) in pediatric cardiac diseases of varies aetiologies. Conclusion: It has been discovered that the cytokine growth differentiation factor-15 (GDF-15) is elevated in a number of clinical states, including hypertension, cardiovascular illness, and oxygen deprivation. GDF-15 is also found to be elevated in HF and PH (pulmonary hypertension). An increased level of GDF-15 is seen in newborns and children with PH-CHD, suggesting its use as a diagnostic biomarker.