Background: Cancer has become one of the most common debilitating systemic diseases, and it's responsible for a large number of worldwide deaths annually, In cancer patients, QoL is affected by the specific diagnosis, its meaning for the patient, the disease's ,   impact on the patient's physical and mental condition, short- and long-term adverse effects of treatment, the  patient's coping mechanisms, and the reactions of their  family members or other individuals .
Objectives: The main objective of this prospective study is to assess the nutritional state of cancer patients and correlate nutritional state with response and tolerability to the treatment line along with the survival of the patients  and help to increase awareness to clinical application of nutritional therapy with oncological therapy.
Patients and Methods: 300 cancer patient,( Age> 18 years - <70 years); 30% of patients presented with breast cancer , 16%  of patients with  colon cancer, 15% of patients with pancreatic cancer ,12 % of patients with NHL ,1% of patients with glioma.
Results: the mean cumulative proportion of event-free patients for the study group was at 0.95 (SE,0.01) at 1 month, 0.88 (SE, 0.02) at 3 months, and 0.75 (SE, 0.03) at 6 months.
Conclusion: Assessment of nutritional status in cancer patients is more accessible and designed through the application of MUST scoring system on patients at the time of first presentation and along the treatment course. It allows signing down all symptoms and changes occur, classification of the patients' conditions and design a treatment protocol according to severity.