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177940

Androgen receptor in relation to progesterone receptor (AR/PR ratio) in non-metastatic hormonal positive, Her2neu negative breast cancer

Article

Last updated: 27 Dec 2024

Subjects

-

Tags

Oncology and Nuclear Medicine.

Abstract

Background: The impact of estrogen/progesterone receptors (ER/PR) is well-established with respect to therapy and prognosis of breast carcinoma. However, the role of androgen receptor (AR) expression is varying among breast cancer subtypes. Objectives: The objective of this study is evaluating relation between androgen receptor to progesterone receptor in non-metastatic hormonal positive Her2-neu negative breast cancer patients. Patients and methods: This study included 100 female patients with breast carcinoma, whose hormone receptor status data were available. Demographic and histopathologic details were retrieved. Immunohistochemistry for AR was done and considered positive if >10% of tumor cells showed nuclear staining. Results: We evaluated 100 female patients with primary breast cancer by using immunohistochemistry. Of the 100 cases, 51 cases had an AR/PR ratio<1.63 and 49 cases had an AR/PR ratio ≥1.63. In the descriptive analysis, patients with a higher AR/PR ratio carried early disease stage and they frequently had negativity for perineural invasion (p value<0.005).  Conclusion: There is no significant association between AR/PR ratio with overall survival and disease free survival. AR/PR could be used to identify patients with different prognosis, their real value needs to be better clarified in different BC settings through prospective studies and larger number of patients.

DOI

10.21608/svuijm.2021.78961.1182

Keywords

Androgen receptor, Breast carcinoma, Androgen receptor /progesterone receptor

Authors

First Name

Maged A.F.

Last Name

Amine

MiddleName

-

Affiliation

Department of Medical Oncology and Hematology Department, South Egypt Cancer Institute, Assuit University, Assuit, Egypt

Email

maged1907@aun.edu.eg

City

assuite

Orcid

-

First Name

Ahmed Mubarak

Last Name

Hefni

MiddleName

-

Affiliation

Department of Medical Oncology and Hematology Department, South Egypt Cancer Institute, Assuit University, Assuit, Egypt

Email

ahmed_mubarak1982@aun.edu.eg

City

assuite

Orcid

-

First Name

Shimaa R.

Last Name

Younis

MiddleName

-

Affiliation

Department of Medical Oncology and Hematology Department, South Egypt Cancer Institute, Assuit University, Assuit, Egypt

Email

shimaradwan94@gmail.com

City

Assuit

Orcid

-

First Name

Tarek M

Last Name

Elsaba

MiddleName

-

Affiliation

Department of Pathology, South Egypt Cancer Institute, Assuit University, Assuit, Egypt

Email

tarek_elsaba@aun.edu.eg

City

assuite

Orcid

-

First Name

Amen H.

Last Name

Zaky

MiddleName

-

Affiliation

Department of Medical Oncology and Hematology Department, South Egypt Cancer Institute, Assuit University, Assuit, Egypt

Email

amenzaky74@yahoo.com

City

assuite

Orcid

-

First Name

Ashraf

Last Name

Zedan

MiddleName

-

Affiliation

Department of Medical Oncology and Hematology Department, South Egypt Cancer Institute, Assuit University, Assuit, Egypt

Email

profzedan@yahoo.com

City

assuite

Orcid

-

Volume

7

Article Issue

1

Related Issue

43681

Issue Date

2024-01-01

Receive Date

2021-06-03

Publish Date

2024-01-01

Page Start

572

Page End

579

Print ISSN

2735-427X

Online ISSN

2636-3402

Link

https://svuijm.journals.ekb.eg/article_177940.html

Detail API

https://svuijm.journals.ekb.eg/service?article_code=177940

Order

61

Type

Original research articles

Type Code

1,520

Publication Type

Journal

Publication Title

SVU-International Journal of Medical Sciences

Publication Link

https://svuijm.journals.ekb.eg/

MainTitle

Androgen receptor in relation to progesterone receptor (AR/PR ratio) in non-metastatic hormonal positive, Her2neu negative breast cancer

Details

Type

Article

Created At

27 Dec 2024