Background: Multiple sclerosis (MS) MS is a demyelinating and neurodegenerative inflammatory disorder of the brain and the spinal cord that is one of the most frequent neurological disorders at a young age. Several MS centers have established MS registries to estimate the prevalence of the disease in the general community and to investigate the clinical characteristics of MS patients. Objectives: Determining the demographic and clinical patients with MS referred to Qena University Hospital. Patients and methods: In a descriptive cross-sectional study on thirty patients clinically diagnosed to have MS according to 2017 McDonald criteria were included. They were diagnosed in the neuropsychiatry department from November 2018 to April 2020. Results: There were 17 (56.6%) females, 13 (43.3%) males, the mean age was 31.65 (± 8.08 SD), the mean duration of illness was 58.98 (± 44.78 SD). Conclusion: This is the first MS register from the governorate of Qena. The clinical features of MS in Qena are comparable to those seen in other Arab and Western countries. Females are more likely to develop MS than males, and visual symptoms were the most frequent manifestations. Our results also illustrate the importance of developing registries in Egypt so that the clinical path of the disease can be studied prospectively.