Background: Autism spectrum disease (ASD) represented as a collection of neurodevelopmental disorders marked by reduced reciprocal socializations and communications. Mood conditions are frequent in autism spectrum disease (ASD).  Objectives: The present work aimed to evaluate prevalence, symptoms and treatment of different types of mood disorders in kids with autism spectrum disorder (ASD), with ages between 2 to 16 yrs. Methods:  We have searched literature in Pub Med and Google scholar. Conclusion: Early age, male gender, low socioeconomic states, residence, consanguinity, old parent's age, represented conditions that are accompanying with a raised hazard for ASD in population. Mood disorder including anxiety, bipolar disorders, depressions, and obsessive-compulsive disease (OCD) beside attention deficit hyper-activity disorders (ADHD) are the utmost occurring co morbidities. Selective serotonin reuptake inhibitor (SSRI) and anti-psychotics were defined for mood disorders management.