Background: Sella turcica is regarded as an important landmark that gives information about craniofacial development in lateral cephalometric radiographs. Malocclusion means disturbance in the arrangement of teeth which affects the general shape of the face , it is divided into 3 classes; I,    II and III . 
Objectives: to identify various anomalies of Sella turcica and their relation with malocclusion. 
Subjects and methods: This retrospective study had been done on 321 lateral cephalograms of persons  aged 5-16 who visited  the Sohag university hospital, they were classified into three classes of malocclusion, and the anomalies of sella turcica in each class were recorded and analyzed. 
Results: The highest prevalence of normal sella turcica was in class I (44.8%), then class III (21.4%) followed by class II (8.5%) The most frequent anomalies were the incomplete bridge and hypertrophic posterior wall. 
Conclusion: There was an association between malocclusion classes and anomalies of sella turcica which should be noticed by orthodontists or clinicians for any interventional treatment.