Background: The choroid is the vascular tissue supplying the outer retina.
Objectives: We are concerned with studying the changes in choroidal thickness related to anti-VEGF injection in diabetic patients.
Patients and Methods: This was a prospective cohort interventional study conducted at South Valley University Hospital, Ophthalmology department and included 40 eyes from 40 patients with diabetic macular edema. Inclusion criteria included adult phakic patients with diabetic macular edema receiving anti vascular endothelial growth factors injections without prior anti-VEGF therapy. All the patients underwent full eye examination , Refraction was done, uncorrected visual acuity, corrected visual acuity were estimated ,Injections were done only one injection every month for three months and the follow up was 6 months after the date of the first injection. OCT Measurements were performed before and after 6 monthes. OCT Measurements were done 3 times and the average was estimated.
Results: The mean decrease in nasal choroidal thickness was 14.4 (SD = 4.3, 95% CI = 13.02:15.78, p value = .000). The mean decrease in subfoveal choroidal thickness was 12.25(SD = 3.59, 95% CI = 11.1:13.4, p value = .000). The mean decrease in temporal choroidal thickness was 13.33 (SD = 4.2, 95% CI = 11.98:14.67, p value = .000).
Conclusion: The temporal, nasal, and subfoveal choroid showed a decrease in thickness after receiving anti-VEGF injections in DME patients. . Further studies are recommended to ascertain the relationship between diabetic retinopathy, anti-VEGF injections & choroidal thickness.