Background: Hyperemesis gravidarum (HG) is a severe form of vomiting that occurs in 0.3-2% of all pregnant women. There is geographic difference in the prevalence of Helicobacter Pylori (H. Pylori). The exact prevalence in Egypt is not well-studied.
Objectives: To detect prevalence and risk factors for H. Pylori in pregnant women with HG.
Patients and Methods: This was a cross-sectional study. The study was conducted at the Department of Obstetrics and Gynecology, South Valley University hospitals.
Results: The study included 100 pregnant women with HG.In this study, the H. Pylori stool antigen testing was positive in 44 cases out of 100 cases, making a prevalence of 44%. Risk factors of H. Pylori was rural residence (adjusted OR: 3.45; CI:1.12-10.94; and P value: 0.03), recurrence of vomiting in the current pregnancy (adjusted OR was 3.85; CI:1.15-12.91; and P value: 0.03), and anemia (adjusted  OR: 0.74; CI: 0.55-0.98; and P value: 0.04)
Conclusion: H. Pylori affects 44% of women with HG. There was significant association between H. pylori and the rural residence, the recurrence of vomiting in the same pregnancy, and the presence of anemia.