Background: Coronary artery disease (CAD) is the most common cause of death globally according to WHO. Its known that ischemia and cardiac dysfunction promotes the angiogenesis and new vessel formation to compensate for the decreased blood supply through the diseased arteries.Angiopoietin-2(Ang-2) along with several other growth factors are responsible for the process of new vessel formation. Many patients have some degree of renal insufficiency post PCI mainly due to contrast media and are associated with rise in the serum Ang-2 level. Ang-2 is found to be decreased post PCI with the restoration of the normal blood flow. Many clinical trials relate the Ang-2 with the severity of CAD and renal function. Objectives: Highlight the serum levels of Ang-2 pre and post PCI and its validity to be used to diagnose and predict severity of CAD. Methods: We have searched literatures in PubMed, google scholar, Egyptian bank of knowledge and science direct. Conclusion: In this review we emphasize that Ang-2 is found to be an important marker for diagnosis and prognosis of CAD and is closely related to renal functions in ischemic cardiac patients candidate for PCI.