Background: Sino-nasal polyps can be treated medically (with systemic and local steroids) or surgically; but a lot of patients refuse surgical intervention or are contraindicated to use systemic steroids. Intra-polyp steroid injections have recently been utilized to deliver high concentrations of steroid directly into the nasal polyp while simultaneously shielding the patient from the systemic steroid side effects.
Objectives: To assess the role and efficacy of intra-polyp injection of steroids in the management of allergic nasal polypi, as well as to compare these findings to those of oral steroid.
Patients and methods: Our study involved sixty patients that attended the outpatient clinic of the ENT department at Qena University Hospital who diagnosed with allergic nasal polypi. Their ages ranged from 17 to 63 years. They were randomly divided into 2 groups (oral steroid and intra-polyp steroid injection) according to type of treatment, each consisting of 30 patients.
Results: After treatment, both groups showed a statistically significant decrease in the Symptom Score, Polyp Score, and Lund-Mackay score (P <0.001), with a significant difference between them (P < 0.001).
Conclusion:  Intra-polyp injection of steroid appears to be a safe and effective treatment method for Sino- nasal polyposis, with results comparable to systemic corticosteroids.