Abstract: The purpose of this research was to determine the effectiveness of using an Interactive Science Notebook (ISN) to develop sixth grade (EFL) pupils' creative thinking skills and their achievement in science in the first semester of the academic year 2021-2022.  It has provided insights about the Interactive Science Notebook (ISN)  influence on pupils' creative thinking skills, and how Interactive Science Notebook (ISN) is an effective learning tool to increase pupils' academic achievement. The research utilized an Interactive Science Notebook. The research sample consisted of (30) participants in sixth grade, the sample was selected from two classes and distributed into two groups: an experimental group (n=14) and the control group (n=16) from Mansoura college language school. The finds showed the effectiveness of Using Interactive Science Notebook in teaching science in developing Some Skills of creative thinking and the achievement in science of primary stage pupils. There are statistically significant differences between the mean scores of the control group and the experimental group in the post-creative thinking skills test and the achievement test and the values of (U) were significant at 0.05 in favor of the experimental group. Keywords:-Interactive Science Notebook, Creative thinking skills, Primary stage, Language schools.