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393483

Effect of Chlorhexidine Mouthwash on Chemotherapy-Induced Oral Mucositis among Patients with Cancer

Article

Last updated: 26 Dec 2024

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Abstract

Abstract: Background: Oral mucositis (OM) is a painful complication of cancer treatment that starts with inflammation in the oral mucosa and progresses to redness and ulcers. Severe pain from ulcers can affect speaking and eating. Purpose: To assess the effect of chlorhexidine mouthwash on chemotherapy-induced oral mucositis among patients with cancer. Design: A quasi-experimental research design was utilized for this study. Setting: The study was conducted at the Oncology Institute (inpatient department & outpatient clinic) at Menoufia University Hospital in Shebin El Koum, Egypt. Sample: A purposive sample of 100 patients who met the inclusion criteria was selected and divided into two equal groups (Study & Control). Instruments: Four instruments were used: Structured interview questionnaire, oral assessment guide, WHO oral mucositis assessment scale and visual analogue pain scale. Results: The study revealed a statistical significant difference between the study group and the control group in terms of oral cavity functions and grades of oral mucositis, with the study  group showing better results post-intervention (P-values <0.001). The study also showed a lower occurrence of oral mucositis in the chlorhexidine group than the control group. Additionally, a highly significant statistical difference was observed between the two groups regarding pain scores in favor of the Chlorhexidine group  in the second and third sessions (P-values <0.001). Conclusions: The study found that chlorhexidine mouthwash reduced oral mucositis grades, mucositis occurrence, and pain severity in the chlorhexidine group. It also reduced deterioration in oral health in the study group compared to the control group. Recommendations: Chlorhexidine mouthwash 0.12% is recommended in combination with routine hospital care to reduce oral mucositis, pain, and improve oral health.

DOI

10.21608/menj.2024.393483

Keywords

Cancer, chlorhexidine, Chemotherapy, Oral mucositis

Authors

First Name

Mahmoud

Last Name

Omara

MiddleName

Sobhy

Affiliation

Clinical Instructor of Medical Surgical Nursing, Faculty of Nursing, Menoufia University, Egypt

Email

mahmoud.sobhy@nursing.menofia.edu.ed

City

-

Orcid

-

First Name

Wafaa

Last Name

Abdullah

MiddleName

H.

Affiliation

Prof. of Medical Surgical Nursing, Faculty of Nursing, Menoufia University, Egypt

Email

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City

-

Orcid

-

First Name

Nasser

Last Name

Abd EL-Bary

MiddleName

Mohamed

Affiliation

Prof. of Clinical Oncology and Nuclear Medicine, faculty of Medicine, Menoufia University, Egypt

Email

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City

-

Orcid

-

First Name

Gehan

Last Name

El madbouh

MiddleName

-

Affiliation

Lecturer of Medical Surgical Nursing, Faculty of Nursing, Menoufia University, Egypt

Email

-

City

-

Orcid

-

First Name

Rahma

Last Name

ELkalashy

MiddleName

Abdelgawad

Affiliation

Assist.Prof. of Medical Surgical Nursing, Faculty of Nursing, Menoufia University, Egypt

Email

rahma.elkalshi@nursing.menofia.edu.eg

City

-

Orcid

-

Volume

9

Article Issue

4

Related Issue

51047

Issue Date

2024-10-01

Receive Date

2024-11-25

Publish Date

2024-10-01

Page Start

125

Page End

142

Print ISSN

2735-3974

Online ISSN

2735-3982

Link

https://menj.journals.ekb.eg/article_393483.html

Detail API

https://menj.journals.ekb.eg/service?article_code=393483

Order

393,483

Type

Original Article

Type Code

1,480

Publication Type

Journal

Publication Title

Menoufia Nursing Journal

Publication Link

https://menj.journals.ekb.eg/

MainTitle

Effect of Chlorhexidine Mouthwash on Chemotherapy-Induced Oral Mucositis among Patients with Cancer

Details

Type

Article

Created At

26 Dec 2024