Abstract: Substance abuse among adolescents poses significant risks to their health and wellbeing. Purpose: To assess the relation between mental resilience and decision-making style among secondary school students prone to substance abuse. Design: A descriptive correlational design was utilized. Setting: This study was conducted at four secondary schools in Menoufia Governorate, Egypt. Sample: A purposive sample of 117 secondary students who fit the inclusion and exclusion crieteria. Instruments: Four eening test (DAST-20) adolescent version Results: Three quarters (75.2%) of studied students had substantial level of drug abuse, and only 23.1% had severe level of drug abuse. More than half of studied students had low resilience, exceptional, high and moderate levels (56.40, 35, 6.80,1.70) respectively. The highest decision-making styles used by studied students were spontaneous, dependent and rational (14.9, 11.4, 11.3) respectively. While the least decision-making styles used by them were avoidant followed by intuitive (10.9, 10.7) respectively. There was a highly statistically significant positive correlation between total resilience and total decision-making Conclusion: There was a positive correlation between total resilience and total decision-making among studied students. Recommendation: incorporate Regular screening for psychological and behavioral problems should be done for secondary school students