Abstract: Background: In today's world, technology is developing rapidly, mobile learning has been playing an important crucial role in nursing education. There is a significant relationship between the use of mobile technologies and learning process of acquiring knowledge and practice.so, it is important to develop effective teaching methods to boost students' knowledge, skills, and satisfaction. Purpose: To assess effect of using Mobile -Based learning Versus Traditional Method for Cardiopulmonary Assessment among Nursing Students Design: A quasi-experimental study. Settings: This study was carried out at the Faculty of Nursing, Beni-Suef University. Sampling: Purposive sample of 190 nursing students at First-year. Instruments: Three instruments were used for data collection: students' structured questionnaire, nursing students' observational checklist and students' satisfaction scale. Results: Students who received mobile based learning were more skillful compared to students who received traditional education (p = 0.013). They also acquired higher knowledge scores (p = 0.029) and greater satisfaction (p = 0.019). Conclusions: It was concluded that students who received Mobile based learning had higher levels of academic practice, knowledge and satisfaction. Recommendations: The study recommended that nursing faculties should adopt mobile based learning to maximize learning experiences and skills development.