Background: Telenursing improve accessibility to health care, faster services development, increase in the esteem of the profession, data security, facilitated communication between nursing staff as well as saving time. Purpose: Assess the awareness and perception of nurses regarding telenursing at primary health care setting. Design: Descriptive research design. sample: All nurses (300) were working at previously mentioned settings. Setting: The study was carried out in primary health care centers, in two districts of Menoufia governorate, Egypt. Instruments: interviewing questionnaire about sociodemographic characteristics, awareness assessment questionnaire about telenursing and nurses' perception scale regarding telenursing. Results: Findings of study revealed that, studied nurse's age was between 20 – 30 years, with mean age 32.9 ± 8.8 years. Furthermore, 90.3% of studied nurses were females. The total number of studied nurses had mobile and 98% of them using internet. Moreover, 77.7 % of studied nurses didn't have training courses on telenursing. In addition, 74% of the studied nurses had poor awareness regarding telenursing. Furthermore, 74% of the studied nurses had very good perception regarding telenursing. Conclusions: The majority of the studied nurses had Poor level of awareness regarding telenursing, while, three quarters of the studied nurses had very good level of perception regarding telenursing. Recommendations: Develop and implement educational training programs to increase awareness and perception about telenursing.