Abstract: Background: Effective talent management is one of the most powerful tools for enhancing the retention of nursing managers and creating environments that encourage nursing managers to remain in their positions. Purpose: To examine the effect of talent management training program for nursing managers on their retention. Design: A quasi-experimental research design was used.  Setting: The study was conducted at Damanhor Medical National Institute. Sample: All available nursing managers (100) were included in the study sample. Instruments: Two instruments were used, which were Talent Management Questionnaire and Nursing Managers' Retention Questionnaire. Results: More than two thirds (68%) of the studied nursing managers had low knowledge level of total talent management at pre- program that improved to more than four-fifths (86%) gained a high knowledge level of total talent management post program. About two thirds (62%) of the studied nursing managers had low level of total retention rate at pre-program that improved to more than four-fifths (88%) had high level post program.  Conclusion: Talent management training program provided a statistical significant positive large effect on nursing managers' retention rate throughout the program phases.  Recommendations: Improving the financial reward/salary and benefits for talented nursing managers needs to be considered to improve their retention rates.