Abstract: Background: Talent management involves a series of practices used in healthcare organizations to attract, select, develop, and manage nursing managers in a cohesive and strategic way that affects their job performance. Purpose: To examine the effect of talent management training program for nursing managers on their job performance. Design: A quasi-experimental research design was used. Setting: The study was conducted at Damanhor Medical National Institute. Sampling: All available nursing managers (100) were included in the study sample. Instruments: Two instruments were used, which were Talent management questionnaire and Job Performance Evaluation Checklist Observational Sheet. Results: More than two thirds (68%) of the studied nursing managers had low knowledge level of total talent management at pre- program that improved to more than four-fifths (86%) at post program. Half (50%) of the studied nursing managers had a poor total job performance level at pre-program that improved to majority (96%) had a good level post program. Conclusion:  Talent management training program provided a statistical significant positive large effect on nursing managers' job performance evaluation throughout the program phases.  Recommendations:   Talent management training program needs to be provided for newly hired nursing managers in the healthcare organization to improve their job performance. Further study need to be conducted on the role of technology in enhancing the job performance of nursing managers and talent management.