Background: The field of anesthesia has seen significant advancements in recent years, with spinal anesthesia being a popular method for surgeries below the umbilicus. However, one complication often associated with spinal anesthesia is post dural puncture headache. Post dural puncture headache is defined as head pain that appears within five days of the dura being punctured. Purpose: was to examine the effect of nursing interventions on headache among patients post spinal anesthesia. Design: a quasi-experimental research design was utilized for this study. Setting: The current study was carried out at general surgery department of  Menoufia Emergency Hospital. Subjects: A purposive sample of 214 adult patients who fulfilled the inclusion criteria was assigned randomly and equally divided into two groups 107 in each group. Instruments: Two instruments were used for data collection structured interview questionnaire and Grading of post dural puncture headache severity. Results: The current study revealed that there was a highly Statistically significant differences between control group and study group regarding severity of headache throughout the study period. Conclusions: nursing interventions had a positive effect on post dural puncture headache and its severity among study group than control group. Recommendations: The current study recommended to generalize these structured nursing measures in the routine post-operative nursing care for patients undergoing spinal anesthesia. More research is needed to investigate the effectiveness of these measures in other types of surgery using spinal anesthesia.