Background: Gynecologic cancer and its treatments can create hopelessness and anxiety and alter the lifestyle of the affected women. In addition, they often lead to sexual changes that impair female identity and sexual functioning which make the development of a multidisciplinary team in order to address patient's psychosexual problems very crucial.  The purpose of the study was to investigate the effect of multidisciplinary team care on psychosexual problems resulting from gynecological malignancies treatment Design: A quasi-experimental research design was utilized. Settings: The study was conducted at Oncology and Surgical Departments of Menoufia University Hospital. Sample: A purposive sample of 110 patients diagnosed with gynecological malignancies and were planned to undergo surgery, chemotherapy or radiation. Instruments: A structured interview questionnaire, the distress thermometer, the hospital anxiety and depression scale and female sexual function index. Results: There was a highly statistically significant difference in the distress score (23.6% and 0% moderate to severe distress) in the study group compared to (80% and 16.4, respectively) in the control group. In addition, there was a marked reduction in mean anxiety level (6.54±1.37) and mean depression level (8.03 ± 1.87) of the study group after receiving the multidisciplinary team care. Also, there was significant improvement in sexual function of the study group (56.4% of the study group demonstrated good sexual function) after the treatment. Conclusion: There was significant improvement on the psychological and sexual wellbeing of the gynecological malignancies patients who received the multidisciplinary team care Recommendations: Integration of multidisciplinary team care in the management of gynecological malignancies patients should be considered in order to address any psychological and sexual needs.