Abstract: Background: Surgery, chemotherapy, radiotherapy and hormonal therapy are very effective in gynecological malignancies treatment but they produce a wide variety of health problems which affect the psychological, sexual, physical and social aspects of patients' health which make the development of a multidisciplinary team in order to provide comprehensive patient care very crucial. The purpose of the study was to investigate the effect of multidisciplinary team care on health problems resulting from gynecological malignancies treatment. Design: A quasi-experimental research design was utilized. Settings: The study was conducted at Oncology and Surgical Departments of Menoufia University Hospital. Sample: A purposive sample of 110 patients diagnosed with gynecological malignancies and were planned to undergo surgery, chemotherapy or radiation. Instruments: A structured interview questionnaire, the distress thermometer, the hospital anxiety and depression scale, female sexual function index and functional assessment of cancer therapy questionnaire. Results: There was a highly statistically significant difference in the distress score (23.6% and 0% moderate to severe distress, respectively) in the study group compared to (80% and 16.4%, respectively) the control group. In addition, there was marked reduction in mean anxiety (6.54±1.37) and depression level (8.03 ± 1.87) of the study group and significant improvement in sexual function of the study group (56.4% of the study group demonstrated good sexual function) after the intervention. Furthermore, there was significant difference in regard to mean physical wellbeing of the study group (48.37± 8.08) in comparison to control group (10.72± 7.83) after the treatment. Additionally, there was significant difference in regard to mean social wellbeing of the study group (78.56 ± 12.51) in comparison to control group (54.84 ± 7.80) after the treatment.  Conclusion: Multidisciplinary team care provided by the oncologist, psychotherapist, gynecologist, nutritionist and nurse resulted in significant improvement on the psychological, sexual, physical and social wellbeing of the gynecological malignancies patients. Recommendations: Integration of multidisciplinary team care in the management of gynecological malignancies patients should be considered in order to address the patient's needs.