Abstract: Critical care nurses deal with a variety of urgent, complicated, and unpredictably occurring situations in their caring units. Non-technical skills and personality traits of nurses can affect their caring behaviors that consequently affect patients' safety. The purpose of the study is to evaluate Perceived patients' safety and its relation to non-technical skills and personality traits among nurses at critical care units. Research design: Descriptive correlational design was employed in this study. Setting: the study was conducted at critical care units in Beni Suef University Hospital. Sample: A convenient sample of 126 staff nurses. Instruments: Four instruments were used; characteristics of nurses structured questionnaire, non-technical skills likert scale, the big five personality traits inventory and nurses' perception of patient's safety likert scale.  Results: The majority of studied nurses (96%) had a satisfactory level of non-technical skills; nearly two thirds of them (67.5%) had high perception of patientsꞌ safety culture. There was a highly statistical significant positive correlation between extroversion and patientsꞌ safety. A statistical significant positive correlation was found between neuroticism and experience. Also, there was a very highly statistical significant positive correlation between conscientiousness and experience. Conclusion: A positive correlation was found between some non-technical skills and patients' safety culture. Furthermore, personality traits in terms of extraversion, conscientiousness, and neuroticism were correlated positively with patients' safety. Recommendations: Health organizations should consider such research studies as a reference for appropriate placement and distribution of nurses on the hospital departments based on their levels of non-technical skills and personality traits. Also, training should be conducted about Non-technical skills especially for nurses at critical care settings.