Abstract: Background: Handoff is crucial for planning patient care, patient evaluation, and patient management. The lack of efficiency with handoff communication among nurses and other health care professionals has been problematic. Purpose: was to study the effect of handoff training program on nurses' interns' knowledge, and communication competence. Design: A quasi-experimental research design was used. Setting: Conducted in different governmental and private hospitals where nursing interns enrolled in internship year 2021-2022 method: 150 of intern nursing students (30%) who enrolled in internship year 2021-2022.Data collection Instruments: Handoff knowledge test and communication competence observational checklist were used. Results: There was marked improvement in handoff knowledge among nurses' interns at posttest and follow up test compared with pretest after implementing of training program. Also, more than half of the nurses' interns had unsatisfactory level of handoff knowledge at pretest but, majority of them had satisfactory knowledge level at posttest and slightly decline at follow up test. Furthermore, there was a highly statistically significance and improvement of nurses' intern's communication competence dimensions through program phases. The communication competence level of intern students was high in posttest and follow up test compared with pretest. Conclusion: there was highly statistically significance correlation between hand-off knowledge and communication competence and there was marked effectiveness of the handoff training program on improving the nurses' interns' communication competence. Recommendations: Provide undergraduate students the opportunities to participate in handoff during clinical area.