Abstract: Background: Endometriosis is a chronic, progressive disease of unclear etiology and is one of the most common gynecological diseases. The purpose of the study was to assess the awareness of nonmedical students at Menoufia University towards endometriosis. Design: A descriptive (cross-sectional) research design was used in this study. Settings: The study was conducted in different faculties of Menoufia University among nonmedical students, namely the Faculty of Arts, Faculty of Specific Education, Faculty of Commerce, Faculty of Law, and Faculty of Mass Communication. The instrument of this study was a structured interview questionnaire that included socio-demographic characteristics of the nonmedical students, family history of endometriosis, and an assessment of the nonmedical students' awareness regarding endometriosis. Results: It shows that 84.0% of them had poor awareness scores, 14.0% had fair awareness scores, and 2.0% had good awareness scores regarding endometriosis. Conclusion: Most of the nonmedical students at Menoufia University had poor awareness scores regarding endometriosis. Recommendations: Increasing the availability of health education programs for non-medical students to increase their public awareness and fundamental knowledge of endometriosis.