Abstract: Background: Oral health among children usually is an indicator of their overall health, well-being and quality of life. Dental caries represents a major public health problem in children making them more liable for poor quality of life. Purpose of the study: Was to assess the quality of life related to oral health for school-age children with dental caries. Design: A descriptive cross-sectional design was utilized. Setting: The study was conducted in primary schools in Menoufia governorate, there were Al Shohadaa and Tala urban and rural schools. Sampling: Multi-stage random sample of 500 children primary school was obtained from the previously mentioned settings. Instruments: Three instruments were utilized for data collection: structured interview questionnaire, quality of life related to oral health Likert scale, and observational dental examination sheet. Results: There were a statistically significant differences between children's total oral health knowledge and there were statistically significant differences between quality of life related to oral health among studied school children. Conclusion: The quality of life related to oral health of school-age children was significantly affected by dental decay in all quality of life related to oral health domains (oral symptoms, functional limitation, psychological status, and social status). Recommendations: Integrating oral health education in the scholastic regular curriculum should be applied for raising the awareness and enhancing the related habits at all education levels.