Abstract: BBackground: Systems thinking plays an important role in any health care institution as they shape and affect the nature of nurses' knowledge, behaviors, skills and attitudes that contribute to deliver safe nursing care within the rapidly altering work environment. Purpose: To determine the relation between systems thinking and safe nursing care among studied nurses at Menoufia University Hospital. Design: A correlational research design was used. Setting: The study was conducted in the critical care units of Menoufia University Hospital. Sampling: A simple random sampling of 250 nurses constitutes the study sample. Two instruments were used they were named Systems Thinking Scale and Assessment of Safe Nursing care questionnaire. Results: Less than two thirds of studied nurses (61.2%)  had high level of systems thinking and more than two thirds of them (70.4%)  had high level of safe nursing care while, the minority of them had low level of both systems thinking and safe nursing care. Conclusion: There was a highly statistically significant positive strong correlation between systems thinking and safe nursing care among studied nurses. Recommendations:  Training programs should be conducted for nurses to enhance nurses' knowledge and skills related to systems thinking and safe nursing care. Further study about barriers affecting systems thinking and safe nursing care in different health care sectors. Perform collaboration protocol between the college of nursing and hospital to improve systems thinking and safe nursing care.