Abstract: Background: Nurses are at risk for presenteeism, a growing occupational health issue that remains unnoticed despite its association with poor health and absenteeism due to illness. Purpose: The study aimed to examine the maternity nurses' perspective of presenteeism and its relation to self-reported quality of care, decision latitude & patient safety culture at the study settings. Research Design: Descriptive correlational research design was utilized. Setting: The study was conducted at maternity departments and maternity operation rooms at Shebin El-Kom University Hospital, Shebin El-Kom Teaching Hospital, El Shohdaa Hospital and Omoma Hospital, Menoufia governorate, Egypt. Sample: All Staff nurses (95) at maternity departments and maternity operation rooms at the previous mentioned settings. Instruments: Data was collected using four standardized scales: (I): Stanford presenteeism scale, (II): Self-reported quality of patient care scale, (III): Decision latitude scale and (IV):  Patient Safety Culture Scale. Results: The highest percentage of the studied nurses experienced presenteeism for better performance (60 %), high self-reported quality of patient care (56.8 %), the total decision latitude (70.1%) and very good perception toward patient safety culture (43.2 %). Conclusion: There was a highly statistically significant positive correlation among maternity nurses' perspective of presenteeism, self-reported quality of care, decision latitude and patient safety culture at the study settings. Recommendations: Nurse managers and supervisors should be familiar with the concept of presenteeism. Focus on presenteeism and not only absenteeism. Conduct further research among nurses to quantify presenteeism, identify its causes and consequences.