Abstract: Background: artificial intelligence has made many advances and developments in the field of nursing. Realizing the extent to which nurse managers know the advantages, problems and their attitudes of artificial intelligence is very important for all stages of artificial intelligence creation in health institution. Purpose: To explore the perception and attitudes of nurse managers toward artificial intelligence technology at selected hospitals.Design: A descriptive correlational research design was used. Setting: The study was conducted at different units at Menoufia University Hospital, National Liver Institute and El-Helal Insurance Hospital at Shebin El-Kom). Sample: Convenience sampling technique was used to select all available nurse managers working at the study settings (166).Instruments: Perception toward artificial intelligence questionnaire and attitude towards artificial intelligence questionnaire. Results: The Majority (84.3%) of nurse managers had moderate level of perceptions towards artificial intelligence and (58.4%) of nurse managers had negative attitude towards using artificial intelligence while (41.6%) of them had positive attitude towards using artificial intelligence technology. Conclusion: There was statistically significant positive correlation between nurse managers' perception towards artificial intelligence technology and their attitudes towards artificial intelligence technology. Recommendations: In-service training and education programs about artificial intelligence to increase nurse managers' knowledge about the benefits, challenges, and problems concerning implementation of artificial intelligence in health care settings.