Background: Digital learning materials are playing a crucial role in our daily technological devices. They help learners and teachers to improve learning process. Purpose: To identify the relationship between digital learning materials and nursing students self -efficacy. Design: A descriptive correlational research design was conducted in this study. Setting: This study was used in Faculty of Nursing at Menoufia University. Sampling: A simple random sample was done to select a number of 479 students from grade three (261) and four (218). Instruments: Two instruments were used. Learner generated digital media questionnaire and online learning self-efficacy scale. Results: The majority of nursing students (58.4%) had high perception of digital learning materials, while less than nine percent of them had low perception of digital learning materials. High percentage of nursing students showed moderate level of self-efficacy. Conclusion: A highly positive statistically significant correlation was found between digital learning materials and self-efficacy. Recommendations: Workshops should be enhanced to provide training about using technology. Further researches at other setting should be conducted about the relation between digital learning materials and self-efficacy.