Abstract: Background: Operating room nurses play a significant role in healthcare teams, so it is crucial to be able to effectively use technology and keep up with changes. Artificial intelligence has the ability to track a nurse's workload, increasing their wellbeing and recognize signs of burnout or stress. Purpose: To examine artificial intelligence robotics utilization in relation to wellbeing, burnout, and stress among operating room nurses. Methods: A descriptive, correlational research design was used among a purposive sample of 55nurses who are working at operating rooms in Ain Shams Specialized hospital. Instruments: Four instruments were used (Unified Theory of Acceptance and Use of Technology, Well-Being Index (WBI) survey, Job stress scale and The Maslach Burnout Inventory General Survey). Results: Among the studied nurses the level of the acceptance of robotics surgery was low (80 %), the well-being was low (60 %), the stress was moderate (90.9 %) and the burnout was moderate (54.5 %).Conclusion:  There was a statistical significant correlation between acceptance and use of information with robotics surgery utilization, wellbeing among studied nurses as (p-value < 0.05) and there was no statistical significant correlation with stress and burnout among studied nurses as (p-value > 0.05). Recommendations: Training courses should be conducted for nursing staff in the operating room about the importance of using the artificial intelligence robotics. Awareness of nursing staff about the main technical problems of artificial intelligence robotics and the importance of regular maintenance in the operating rooms should be increased. Further research should be conducted on utilization of artificial intelligence robotics in nursing practice.