Background: Conduct disorder is among the most serious and complex complications in school-aged children. It is considered the leading cause of parental emotional and psychological problems affecting their psychological wellbeing. Purpose: Evaluate the effect of psycho-educational program on emotional distress and psychological wellbeing for parents of children with conduct disorders.  Research design: A quasi-experimental research design two groups (study and control group pre/ posttest) was used to achieve the purpose of the study. Setting: The study was conducted at out-patient psychiatric clinic at Menoufia University Hospitals, in Shebin El-Kom City, Menoufia Governorate. Sample: A convenience sample consisted of 100 parents from the above mentioned setting who fulfilled the inclusion criteria of the study. Instruments: (1): Socio-demographic structured interview questionnaire. (2) The emotional distress scale. (3) Scale of psychological wellbeing. Results: The results revealed that there was a highly statistically significant difference between study and control group in the total emotional distress and psychological wellbeing level post psycho-educational intervention. Conclusion: It was concluded that the psycho-educational intervention has a positive effect on reducing emotional distress and improving psychological wellbeing among parents having conduct disorder children. Recommendations: counseling, family therapy, free workshops for parents because they are really in need.  Furthermore, raising the awareness of nurses and healthcare professionals about parents' experiences of parenting a child with Conduct disorder has the potential to guide practice and provide appropriate support for these mothers, thus minimizing the possible negative impact on their family life.