Background: Diabetic retinopathy is considered a highly specific vascular complication for diabetes and is the most leading cause of blindness in working age which occurs in one third of diabetic patients. Purpose: To examine the effectiveness of an educational intervention on self-care management of patients with diabetic retinopathy. Design: A quasi experimental design was used. It was conducted in outpatient clinic of Kafr El-Sheikh New Ophthalmology Hospital. A convenience sample of 140 patients with diabetic retinopathy was included. Instruments: I- An interviewing questionnaire was used that include socio-demographic data. II- self-care Assessment Questionnaire. III- prognosis checklist of patient's blood sugar, blood pressure and vision. Results: The present study revealed that the educational intervention for patients with diabetic retinopathy leaded to a highly significant improvement (p<0.0001) in the different categories of total practice about self-care practice for diabetic retinopathy. The post program' safe practice responses increased from zero% pre-intervention to > 90% for post intervention. Conclusion: Implementing of a designed educational intervention has a significant role in improving self-care practices among studied patients with diabetic retinopathy. Recommendations: Emphasizing the importance of self-care practices and describing in detail, because this can reduce the risk of DR and its subsequent complications as loss of vision