Background: Playing video games is an interactive form of distraction that is used to divert children focus away from uncomfortable stimuli to lessen pain. Purpose of this study was to evaluate the effect of video games on postoperative pain among preschool children. Design: a quasi-experimental design was used. Setting: it was conducted in the pediatrics surgical unit at Beni-Suef University Hospital. Sample: a purposive sample of 88 hospitalized children were included. Data collection: three instruments were used to gather the data. A structured interview questionnaire, Toddler-Preschooler Postoperative Pain Scale, and Children's Hospital of Eastern Ontario Pain Scale. Results: the results of this study revealed that there were highly statistically significant differences between pain intensity pre-, during and posttest playing video games. As well as there were a highly statistically significant differences between studied children regarding their vital signs (respiratory and heart rate) pre-, during and post playing videogames. Conclusion: this study concluded that Implementation of video games had significant effect in alleviation of post-operative pain level among studied preschool children on the posttest compared to the pretest. Recommendation: this study recommended that ongoing health education programs based on application of video games distraction technique for parents should be implemented to manage post-operative pain.