Chemotherapy Induced Phlebitis (CIP) is an unpleasant side effect of peripheral intravenous therapy, particularly after chemotherapy. The nurses take precautions to avoid the development of (CIP). Using Sesame oil and cold compresses can play an important role in reducing CIP. Purpose: To examine the effect of preventive measures on chemotherapy induced phlebitis among patients with cancer. Setting: The study was conducted in the outpatient clinic and the Oncology department of Menoufia University Hospital. Research design: A quasi-experimental (study/control) research design was utilized.  Subjects: A consecutive sample of 100 adult patients with cancer of both sexes who were receiving chemotherapy treatment was selected. Instruments: instrument (I): Structured Interview questionnaire: instrument (II): Vein Quality Assessment Tool (VAT), and instrument (III): Visual Infusion Phlebitis (VIP) scale. Results: There was a highly statistical significant difference between both groups related to Chemotherapy Induced phlebitis post intervention (p<0.001). Conclusion: applying Sesame oil and cold compress have positive significant effect on preventing chemotherapy induced phlebitis. Recommendation: Oncology patients should be educated about identifying and reporting any changes in their vein condition. Collaborating with other institutions to implement Sesame oil and cold compresses as a preventive measures to reduce the incidence of (CIP) among patients who were receiving chemotherapy.