Abstract: Cardiac catheterization is considered as the gold standard practice for the diagnosis and treatment of coronary artery disease. So, nursing care pre, intra and post procedure regarding patient' safety is very crucial to prevent cardiac catheterization complications .Purpose: is to evaluate the effect of patient's safety educational program on nurses' performance for patients undergoing cardiac catheterization. Design: Aquasi experimental research design was utilized. Setting: The study was conducted in cardiac catheterization unit, cardiac care unit at Menoufia University Hospital and Shebin El-Kom Teaching Hospital. Sample: A convenience sample of all available nurses 40 nurses who are working in the selected setting were selected. Instruments: Two instruments were used for data collection: Structural interview questionnaire and Observational checklist. Results: There was a highly statistical significant improvement in nurses' grand total knowledge mean score in post program implementation phase and in follow up phase  (76.9± 11.5 and 75.5±13.6 respectively) than pre program phase (43.9 ±3.9). Also, there was a highly statistically significance improvement in nurses' grand total performance of cardiac catheterization procedure mean score in post program implementation phase and in follow- up phase (158.2± 2.3 and 156.2±3.0) than pre program implementation phase (93.3±13.5). Conclusions: patient's safety educational program was effective in improving nurses' knowledge and performance for patients undergoing cardiac catheterization. Recommendations: The study suggested equipping cardiac catheterization unit with simple illustrated educational guidelines covering performance and knowledge pre/post cardiac catheterization procedure.