Background: Post-extubation stridor occur in less than one quartile between extubated patients and it may be asymptomatic or mildly symptomatic for ICU staff. Extubated patients may need reintubation after extubation, which increases the mortality rate among those patients.  Purpose: To study the effect of implementing selected nursing interventions on experiencing post-extubation stridor in ventilated patients. Design: A quasi-experimental research design. Study participants: A Purposive sample of 200 patients were included, divided into 50 patients in each of the control and intervention groups. Setting: General intensive care units at governmental hospitals of Albeheria government  in Egypt. Methods: A Purposive sample from adult mechanically ventilated patients admitted to the selected study settings. Intubated patients with the end-stage disease were planned for tracheostomy, but those with a history of multiple extubation trial failures were excluded from the study. Instruments: Two instruments were used, instrument one assessed demographic and clinical data and risk factors associated with post-extubation stridor. Instrument two assessed post-extubation stridor manifestations, Clinical outcomes associated with the post-extubation stridor assessment instrument. Results: The selected nursing interventions decreased the clinical manifestations of post-extubation stridor, reintubation need, and ICU length of stay with percentage changes of -16%, -49.25, and -29.97. They improved the oxygenation indexes, such as PaO2 (% change12.62), SaO2 (% change 5.161), and ROX index (% change 44.37). Moreover, ventilation parameters improved in the minute ventilation (% change-17.4) and PaCO2 (% change -9.09) of the intervention group. Conclusion: The selected nursing interventions improved ventilation and oxygenation parameters associated with post-extubation stridor clinical manifestations. Recommendations: Further studies should be conducted to assess the long-term outcomes of selected nursing interventions