Background: Uterine diseases in recent years have been increasingly prevalent, with patients showing a trend of a younger age. Hysterectomy is one of the most common surgeries for treating many uterine diseases. The influences of hysterectomy on maternal health are linked to physical, economic, sexual, and psychological consequences. Purpose: this study was conducted with the purpose of evaluating the effect of psychological counseling program on quality of life among post-hysterectomy women. Methods: Research Design: A quasi –experimental design. Instruments: Two instruments were used throughout the course of this study: (I) interviewing questionnaire, (II) quality of life questionnaire. Results: psychological counseling program improved quality of life among post-hysterectomy women in the study group (87.1%) than control group (66.1%). Conclusion: The current study findings succeeded in testing research hypothesis. Recommendations: Women experiencing hysterectomy need emotional, social support, and psychosocial support to increase their feeling of security.