Background: Coping strategies can influence treatment outcomes and survival rates of women after mastectomy. Purpose: was to assess the coping strategies of women after mastectomy.  Methods: A descriptive (cross-sectional) design was utilized. A purposive sample of 100 women after mastectomy was chosen. The study was conducted at the Female Surgical Department, Oncology Clinics of Menoufia University Hospital, Shebin El-Kom Teaching Hospital, and Oncology Hospital in Menoufia Governorate. A structured interviewing questionnaire, an observational checklist, and an adaptive coping strategies questionnaire were used. Results: The majority of the studied women (82.0%) had a low coping level after mastectomy. Conclusion: The majority of the studied women had a low coping strategy after mastectomy. Recommendations: Women after mastectomy are advised to receive coping strategies toward managing or dealing with a stressor. Future studies are needed to focus on the adaptive coping strategies that optimize the health of women with breast cancer living with one breast after a mastectomy.