This research aimed at examining the direct impact of Human talent management on organizational entrepreneurship in main branches of commercial banks in Alexandria Governorate and exploring whether Job crafting plays a mediating role in this relationship. The research began with a literature review on Human talent management, organizational entrepreneurship and Job crafting followed by developing a conceptual framework and formulating four main hypotheses. A field study was then conducted using a sample of 291employee at three administrative levels (top – middle - executive) at main branches of commercial banks in Alexandria Governorate and the number of completed questionnaires is 272. Collected data were analyzed using the SEM. Statistical results revealed that all dimensions of the human talent management (talent attraction , talent development , talent retention , talent deployment and talent selection) have a statistically significant positive direct impact on organizational entrepreneurship in main branches of commercial banks in Alexandria Governorate. Regarding the direct impact of Human talent management dimensions on Job crafting, it was found that all dimensions of Human talent management have a statistically significant positive direct impact on Job crafting .Moreover, Statistical results also revealed that Job crafting has a statistically significant direct impact on organizational entrepreneurship. Finally, regarding the mediation of Job crafting, findings showed that Job crafting plays a mediating role in the relationship between Human talent management and organizational entrepreneurship in main branches of commercial banks in Alexandria Governorate.