Background: Hemoglobinopathies that require transfusions are among the most prevalent hereditary disorders in the
world. Transfusion-dependent hemoglobinopathies cause unpredictable, recurrent, and frequently permanent pain,
making them distinct from other pain syndromes. Objective: - This paper aims to evaluate the experience of pain in
children diagnosed with transfusion dependent hemoglobinopathies. Additionally, it seeks to explore the associations
between pain and various sociodemographic and clinical factors in the sample of children under study. Methodology:
This cross-sectional, descriptive study comprised a sample of children between the ages of 8 and 18 years who had
transfusion-dependent hemoglobinopathies. The data was obtained from the hematology clinic located at Children's
Hospital, affiliated with Mansoura University in Egypt. The data was collected by the utilization of a semi-structured
interview form and the implementation of the revised-Face, Leg, Activity, Cry, and Consolability scale (r-FLACC).
Results: Of the children who participated in the research, two-thirds (66%) were female, and 76% had been diagnosed
with beta-thalassemia. Of the children who participated in the study, over half (56%) experienced significant pain
symptoms. Children with sickle cell disease who undergo twice-monthly blood transfusions and have been studied report
experiencing severe pain. Conclusion: Of the children who participated in the study, over half experienced severe pain
symptoms. Types of transfusion-dependent hemoglobinopathies, particularly sickle cell disease, and twice-monthly
blood transfusions, have been linked with severe pain levels. Recommendations: - Regular evaluations and improved
pain management programs aimed at pain reduction, would significantly enhance the well-being of pediatric patients
diagnosed with transfusion-dependent hemoglobinopathies.