Background: Infantile colic is a condition in which an infant shows signs of distress and parents especially mothers not
know what the cause of the infant's crying and how to deal with it so it is very important to enhance mothers' knowledge
and practices related to infantile colic to enhance quality of life of both family and their infants. Aim of the Study: This
study aimed to evaluate effect of educational program for mothers about care of their infants with infantile colic. Design:
A quasi-experimental research design was utilized in this study. Setting: the study was conducted at the Pediatric
Emergency Department and Outpatient Clinics (Pediatric General Clinic) affiliated to Mansoura University Children's
Hospital (MUCH). Subjects: A purposive sample of (246) mothers who attended the previously mentioned settings with
their infants. Tool: one tool contains four parts used: - (I): Characteristics of the studied sample, (II): Medical and
nutritional history, (III): Mothers' knowledge about care of infantile colic, and (VI): Mothers' reported practice about
care of infantile colic. Results: revealed that a less than one quarter of the studied mothers had good knowledge at the
pre-educational program and improved to be less than two thirds at post- educational program, Also, about three-quarters
of them had unsatisfactory reported practices at the pre- educational program that decreased to be minority of them had
unsatisfactory reported practices at the post- educational program. Conclusion: There was a highly statistically
significant positive correlation between pre and post educational program on the studied mothers' total knowledge and
total reported practices level. Recommendations: Encourage breastfeeding during infantile colic episodes and provide
continuous educational programs to improve mothers' knowledge and practices regarding the care of their infants with
infantile colic.