Coronavirus Disease (COVID-19) pandemic is an international public health emergency in many countries all
over the world that affects millions of people. The rapid spread of the COVID-19 pandemic declares great challenges for
healthcare workers, especially dental practitioners. Thus, the current study aimed to assess dental practitioners'
knowledge and performance regarding coronavirus-19 pandemic infection prevention and control measures at Mansoura
Specialist Hospital. Through a descriptive cross-section study design; 25 dental practitioners were involved
conveniently. The researcher collected their socio-demographic and occupational characteristics, assessed their
knowledge with two self-administrated structured questionnaires, and observed performance through an observational
checklist. Results declare that 92.0% and 44% of the dental practitioners had an incompetent level of knowledge and
performance respectively regarding the COVID-19 pandemic infection prevention and control measures. The researcher
concludes that; incompetence is the dominant level in most and less than half of dental practitioners' knowledge, and
performance respectively; regarding infection prevention and control measures during the COVID-19 pandemic. And
finally recommends performing scheduled on-job training programs for dental practitioners on infection prevention and
control measures regarding the COVID-19 pandemic to update their knowledge and performance.