Background Nurses' spiritual well-being directly influenced by religious belief that likely to improve caring
behavior and quality of work life. Aim: search for the relation among spiritual well-being with quality of work life and
caring behavior among nurses at Oncology Center- Mansoura University. Subjects and methods: At the Oncology
Centre of Mansoura University, a descriptive correlational study design was used with a practical sample of (180) staff
nurses. Three tools were used to gather the data as, Spiritual Well-Being Scale, Quality of Work Life Questionnaire and
Caring Behaviors Inventory. Results: Majority of staff nurses were satisfied level about total spiritual well-being,
slightly near to half of staff nurses have high level about quality of work life and more than half of studied nurses have
good level of caring behavior. In addition, there was highly statistically significant positive correlations were found
between total spiritual well-being scores and both total quality of work life and total caring behavior. Conclusion:
Spiritual well-being improve nurses' quality of work life and caring behavior. Recommendations: Including culture in
hospital policies by allowing all staff nurses to have a voice in decision-making. Offering training classes, workshops,
and initiatives to improve and maintain nurses' compassion and spiritual health. Using the QWL program to raise
productivity, organizational commitment, and work satisfaction among nurses.