Background: Presence of narcissistic leadership in health care organization creates bias and disappointment
among nurses, this fosters a culture of negative attitude toward the health care system which leads to organizational
cynicism that make nurses unable to do her job well and the work loss its meaning. Aim: to investigate narcissistic
leadership, organizational cynicism and their relation with meaningful work among nurses at Main Mansoura university
hospital and Mansoura general hospital. Method: A Comparative descriptive research design was utilized with a
sample of (162) nurses at Main Mansoura university hospital and (180) nurses at Mansoura General Hospital. Tools of
data collection were narcissistic personality tool, organizational cynicism scale and the work and meaning inventory
scale. Results: The studied nurses had moderate level of narcissistic leadership at both hospitals (43.8%), (58.9%)
respectively. The studied nurses had low organizational cynicism at both hospitals (85.2%), (76.7%) respectively. The
studied nurses had low meaningful work at both hospitals (85.2%) respectively (76.7%) respectively. Conclusion:
there was a negative non-significant relationship between narcissistic leadership and meaningful work at both hospitals
.There was no statistically significant relationship between organizational cynicism and meaningful work at both
hospitals. Recommendations: Conduct regular training sessions about leadership skills and organizational inclusion
that positively impacts leaders' behavior and stimulate their openness to other views, provide performance incentives,
promotions, and bonuses for nurses to make their work more meaningful.